High-Fat Diet Aggravate the Glycolipid Metabolic Disorder in Offspring Mice of Gestational Diabetes Mellitus

Author(s): Chunxue Xu, Guohui Jiang, Lixia Ji

Gestational diabetes mellitus (GDM) changes maternal uterine microenvironment, increasing the risk of metabolic diseases in offspring in adult. In this study, we explored the effects of diet intervention on glucose and lipid metabolism in adult mice of GDM offspring. The GDM mice model was established by high-fat diet (HFD), and the 8-week aged offspring-mice were randomly divided into Chow group and HFD group. Four weeks later, the levels of OGTT, serum total cholesterol (TC) and triglyceride (TG) were monitored. The results showed that the levels of blood glucose, serum TC and TG in the offspring of HFD group were significantly increased, especially in GDM-HFD group, but there was no significant difference between Normal-Chow group and GDM-Chow group. These data showed that under chow diet, the glucose and lipid levels of GDM offspring increased slightly, but under high metabolic stress, glucose and lipid metabolism were markedly disordered, which emphasized that high-calorie diet could aggravate the disorder of glucose and lipid metabolism in GDM-offspring mice.

Gestational Diabetes Mellitus, Dietary Intervention, Glucose And Lipid Metabolism, Offspring

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