Progress in the Treatment of Neonatal Respiratory Distress Syndrome

Author(s): Hu Hui, Jun Li

With the rapid development of perinatal medical technology and the maturity of the neonatal transport system, the survival rate of premature infants, especially the very low and extremely low birth weight infants, has increased significantly, which has prompted various problems of neonatal respiratory distress syndrome became the research focus of neonatologists, it also makes many scholars at home and abroad increased the research depth of the disease. In the treatment, the continuous improvement of the quality of pulmonary surfactant, the application of various ventilation modes and the clinical application of INSURE and LISA technology have also greatly improved the survival rate of children with NRDS. In recent years, fluid ventilation and extracorporeal membrane lung (ECMO) have also emerged, which alleviates the difficult situation of transport and rescue of critically ill children to a certain extent. This paper reviews the progress of diagnosis and treatment of NRDS.

Neonatal, Neonatal Respiratory Distress Syndrome, Progress in Treatment

1. Ancel PY, Goffinet F, EPIPAGE-2 Writing Group. et al. Survival and morbidity of preterm children born at 22 through 34 weeks’ gestation in France in 2011: results of the EPIPAGE-2 Cohort Study. JAMA Pediatr 2015;169:230–8.
2. Darmaun D, Lapillonne A, Simeoni U, et al. Parenteral nutrition for preterm infants: Issues and strategy. Arch Pediatr. 2018;25(4):286-294. doi:10.1016/j.arcped.2018.02.005
3. Wong JJ, Ong C, Han WM, et al. Protocol-driven enteral nutrition in critically ill children: a systematic review[J]. JPEN J Parenter Enteral Nutr, 2014, 38(1): 29-39.
4. Darmaun D, Lapillonne A, Simeoni U, et al. Parenteral nutrition for preterm infants: Issues and strategy. Arch Pediatr. 2018;25(4):286-294. doi:10.1016/j.arcped.2018.02.005。
5. Naderi H M，Murray JC, Dagle JM. Single Mutations in ABCA3 Increase the Risk for Neonatal Respiratory Distress Syndrome in Late Preterm Infants （Gestational Age 34-36 Weeks）[J].Am J Med Genet A，2015，164A （10）：2676-2678.
6. Kim HC, Suresh MV, Singh VV,et al.Polymer Lung Surfactants. ACS Appl Bio Mater.2018 Sep 17;1(3):581-592.
7. Verder H, Agertoft L, Albertsen P, et al. Surfactant treatment of newborn infants with respiratory distress syndrome primarily treated with nasal continuous positive air pressure: a pilot study [in Danish]. Ugeskr Laeger. 1992; 154: 2136-2139。
8. Leone F, Trevisanuto D, Cavallin F, Parotto M, Zanardo V. Efficacy of InSurE during nasal CPAP in preterm infants with respiratory distress syndrome, Minerva Pediatr, 2013; 65:187-192
9. Isayama T, Chai-Adisaksophia C, McDonald SD. Noninvasive ventilation with vs without early surfactant to prevent chronic lung disease in preterm infants. A systematic review and meta-analysis. JAMA Pediatr 2015; 169:731-739
10. Wyckoff M H, Aziz K, Escobedo M B, et al. Part 13: Neonatal resuscitation: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care[J].Circulation,2015, 132(18):543-603.
11. Aldana-Aguirre JC, Pinto M, Featherstone RM, Kumar M. Less invasive surfactant administration versus intubation for surfactant delivery in preterm infants with respiratory distress syndrome: a systematic review and meta-analysis. Arch Dis Child Fetal Neonatal Ed. 2017;102(1):F17-F23. doi:10.1136/archdischild-2015-310299.
12. Sweet DG，Carnielli V，Greisen G，et al. European Consensus Guidelines on the Management of Respiratory Distress Syndrome—2019 Update［J］. Neonatology，2019，115（4）：432⁃450. DOI：10.1159/000499361.
13. Bertini G, Coviello C, Gozzini E, Bianconi T, Bresci C, Leonardi V, et al. Change of cerebral oxygenation during surfactant treatment in preterm infants: “LISA” versus "InSurE" procedures. Neuropediatrics. 2017;48(2):98–103
14. Hanke K, Rausch TK, Paul P, Hellwig I, Krämer C, Stichtenoth G, et al. The effect of less invasive surfactant administration on cerebral oxygenation in preterm infants. Acta Paediatr. 2020;109(2):291–9
15. Ambulkar H, Williams EE, Hickey A, Bhat R, Dassios T, Greenough A. Respiratory monitoring during less invasive surfactant administration in the delivery suite. Early Human Development. 2021;154:105311.
16. Härtel C, Paul P, Hanke K, Humberg A, Kribs A, Mehler K, et al. Less invasive surfactant administration and complications of preterm birth. Sci Rep. 2018;8(1):8333
17. Cartwright Robert D,Crowther Caroline A,Anderson Peter J, et al. Association of Fetal Growth Restriction With Neurocognitive Function After Repeated Antenatal Betamethasone Treatment vs Placebo: Secondary Analysis of the ACTORDS Randomized Clinical Trial[J]. Jama network open,2019,2(2):e187636.
18. Sardesai S, Biniwale M, Wertheimer F, Garingo A, Ramanathan R. Evolution of surfactant therapy for respiratory distress syndrome: past, present, and future. Pediatr Res. 2017;81(1-2):240-248. doi:10.1038/pr.2016.203。
19. Kattwinkel J, Fleming D, Cha CC, et al. A device for administration of continuous positive airway pressure by the nasal route[J]. Pediatrics, 1973,52(1):131-134.
20. Chen C Y, Chou A K, Chen Y L, et al. Quality Improvement of Nasal Continuous Positive Airway Pressure Therapy in Neonatal Intensive Care Unit[J]. Pediatrics and Neonatology,2017,58(3):229-235.
21. Jensen EA. Prevention of bronchopulmonary dysplasia: a summary of evidence-based strategies. Neoreviews 2019;20(4):e189-e201.
22. Rüegger CM, Owen LS, Davis PG. Nasal Intermittent Positive Pressure Ventilation for Neonatal Respiratory Distress Syndrome. Clin Perinatol. 2021;48(4):725-744. doi:10.1016/j.clp.2021.07.004
23. Owen LS, Manley BJ. Nasal intermittent positive pressure ventilation in preterm infants: Equipment, evidence, and synchronization. Semin Fetal Neonatal Med. 2016 Jun;21(3):146-53.
24. Lemyre B, Laughon M, Bose C, et al. Early nasal intermittent positive pressure ventilation (NIPPV) versus early nasal continuous positive airway pressure (NCPAP) for preterm infants[J]. Cochrane Database Syst Rev,2016,12(12):CD005384.
25. Lemyre B, Davis PG, De Paoli AG, et al. Nasal intermittent positive pressure ventilation (NIPPV) versus nasal continuous positive airway pressure (NCPAP) for preterm neonates after extubation. Cochrane Database Syst Rev. 2017 Feb 1,2 (2):CD003212.
26. Salvo V, Lista G, Lupo E, et al. Comparison of three non-invasive ventilation strategies (NSIPPV/BiPAP/NCPAP) for RDS in VLBW infants. J Matern Fetal Neonatal Med. 2018;31(21):2832-2838. doi:10.1080/14767058.2017.1357693
27. Sadeghnia A, Barekateyn B, Badiei Z, Hosseini SM. Analysis and comparison of the effects of N-BiPAP and Bubble-CPAP in treatment of preterm newborns with the weight of below 1500 grams affiliated with respiratory distress syndrome:A randomised clinical trial. Adv Biomed Res.2016;5:3
28. Capasso L, Borrelli AC, Cerullo J, et al. Reducing post-extubation failure rates in very preterm infants: is BiPAP better than CPAP? [published online ahead of print, 2020 Apr 7].J Matern Fetal Neonatal Med.2020;1-6.
29. Cimino C, Saporito MAN, Vitaliti G, et al. N-BiPAP vs n-CPAP in term neonate with respiratory distress syndrome. Early Hum Dev.2020; 142: 104965
30. Guimaraes AR, Rocha G, Rodrigues M, Guimaraes H. Nasal CPAP complications in very low birth weight preterm infants. J Neonatal Perinatal Med 2019 [Epub ahead of print] doi: 10.3233/NPM-190269
31. Lavizzari A, Colnaghi M, Ciuffini F, Veneroni C, Musumeci S, Cortinovis I, Mosca F. Heated, humidified high-flow nasal cannula vs nasal continuous positive airway pressure for respiratory distress syndrome of prematurity: a randomized clinical noninferiority trial. JAMA Pediatr 2016 [Epub ahead of print] doi: 10.1001/jamapediatrics.2016.1243.
32. Firestone KS, Beck J, Stein H. Neurally Adjusted Ventilatory Assist for Noninvasive Support in Neonates[J]. Clin Perinatol,2016,43(4):707-724.
33. Chawla S, Natarajan G, Shankaran S, et al. Markers of Successful Extubation in Extremely Preterm Infants, and Morbidity After Failed Extubation[J]. The Journal of pediatrics,2017,189.
34. Bamat N, Millar D, Suh S, Kirpalani H. Positive end expiratory pressure for preterm infants requiring conventional mechanical ventilation for respiratory distress syndrome or bronchopulmonary dysplasia. Cochrane Database Syst Rev. 2012;1:CD004500. Published 2012 Jan 18. doi:10.1002/14651858.CD004500.pub2
35. Zhou B，Zhai JF，Wu JB，et a1．Different ventilation modes combined with ambroxol in the treatment of respiratory distress syndmme in premature in premature infants [J].Exp Ther Med，2017，13(2)：629—633．
36. Yang MC, Hsu JF, Hsiao HF, et al. Use of high frequency oscillatory ventilator in neonates with respiratory failure: the clinical practice in Taiwan and early multimodal outcome prediction[J]. Sci Rep, 2020 Apr 20,10(1):6603.
37. Samransamruajkit Ｒ，Ｒassameehirun C，Pongsanon K，et al. A comparison of clinical efficacy between high frequency oscillatory ventilation and conventional ventilation with lung volume recruitment in pediatric acute respiratory distress syndrome: a randomized controlled trial ［J］．Ind J Crit Care Med，2016，20 ( 2) : 72.
38. Sklar MC, Fan E, Goligher EC. High-frequency oscillatory ventilation in adults with ARDS: past, present, and future[J]. Chest, 2017, 152(6): 1306-1317.
39. Clark RH. Manual of neonatal respiratory care[M]. Germany:Springer, 2017: 337-345.
40. Rey-Santano C, Mielgo V, Gastiasoro E, Valls-i-Soler A, Murgia X. Effect of surfactant and partial liquid ventilation treatment on gas exchange and lung mechanics in immature lambs: influence of gestational age. PLoS One. 2013; 8(2): e56127.
41. Fletcher K, Chapman R. Keene S. An overview of medical ECMO for neonates. Semin Perinatol. 2018;42(2):68-79.
42. Rocha G, Soares P, Goncalves A. et al. Respiratory Care for the Ventilated Neonate. Can Respir J. 2018;2018: 7472964. Published 2018 Aug 13.
43. Chinese Neonatologists Association, Chinese Medical Doctor Association; Editorial Board, Chinese Journal of Pediatrics. [Consensus on extracorporeal membrane oxygenation support for neonatal respiratory failure]. Zhonghua Er Ke Za Zhi. 2018 May 2;56(5):327-331. Chinese. doi: 10.3760/cma.j.issn.0578-1310.2018.05.003. PMID: 29783816.