Study on the Effect of LHA on Feeding and its Mechanism

Author(s): Wang Zhongxiang, Wang Mi, Wang Qian, Sun Xiangrong, Xu Luo

Objective: To study the effect of lateral hypothalamic area on feeding and its specific mechanism. Methods: Intraventricular catheterization was used in rats,GLP-1 receptor agonist Ex4 or GLP-1 receptor antagonist Ex9 were injected into the lateral hypothalamic area (LHA) of rats, and the effects of food intake, water intake, body weight, kaolin intake and high-carbonhydrate diet were observed. Results: Immunohistochemical experiments showed the presence of GLP-1 receptor LHA in rats; When GLP-1 receptor was excited, the 1h and 24 h food intake of rats decreased, and the body weight decreased , and there was no significant change in the kaolin intake in rats; When GLP-1 receptor was blocked, there was no significant change in 24h food intake but weight gain in rats; When GLP-1 receptor was excited, high-carbonhydrate diet significantly reduced but there was no significant change in water intake; When GLP-1 receptor was blocked, high-carbonhydrate diet significantly increased but there was no significant change in water intake. Conclusion: GLP-1 receptor can be involved in the regulation of feeding behavior, and the signal may be related to the hedonicproperties of food.

Food intake, GLP-1, LHA

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