Effect of High Fructose Diet during Pregnancy on Progeny Metabolic Syndrome

Author(s): XIAO Zi-yi, HAN Lei, HE Juan, ZHAO Ting, WU Ruo-nan

Objective: To investigate the effect of high fructose diet during pregnancy on insulin resistance in the offspring. Methods: normal diet Wistar adult male rats and female rats were mated and pregnant rats were randomly divided into five groups: normal control group, normal dose group, high dose of fructose fructose group, high dose group and high dose of sucrose fructose group were given daily during pregnancy, 2mL of distilled water, 2g/kg 18g/kg, 6g/kg, 18g/kg and the fructose solution of sucrose solution by gavage, continuous intervention until delivery, delivery of rats fed with basic diet, and the rats weighing body weight, fasting blood glucose. The OGTT test was conducted at the end of the eighth week. After the next day of fasting 12h, the rats were killed, anesthesia, blood extraction, liver HE staining, serum insulin level, and insulin resistance index were measured. Results: during continuous intervention, birth weight childbirth offspring rats; OGTT test: at 30min, high dose group, high dose of fructose fructose group and high dose glucose sucrose group were significantly higher than normal control group and normal group (P<0.05), fructose dose at 120min, high dose group, high dose of fructose fructose group and high dose glucose sucrose group were significantly higher than normal control group (P<0.05). The serum insulin and insulin resistance index of high dose fructose group, super high fructose group and super high sucrose group were significantly higher than those of normal control group and normal dose fructose group (P<0.05). The liver slices of high fructose group and super high fructose group showed fat accumulation. Conclusion: high fructose diet during pregnancy could increase the risk of progeny metabolic syndrome.

Fructose, Fetal, IR, Blood Glucose

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