Effect of Dimethylaminoethano and Compound Amino Acid on Periostin and Dermatopontin Expression in the Skin of D-galactose Induced Aging Model in Rats

Author(s): Jie Yu Yang, Su Liu

Objective: To study the effect of dimethylaminoethano (DMAE) and compound amino acid inject (AA) by mesotherapy on Periostin and Dermatopontin expression levels of D-galatose induced chemical skin aging rat. Method: by using 80 randomly selected wistar rats divided into normal control group, the aging control group and the experimental groups. At the 18th day after D-gal induction, the experimental group were treated with intra-dermal microinjection of 0.2% DMAE + AA, 0.1% DMAE + AA, 0.2% DMAE, 0.1% DMAE, AA and NS on bilateral buttocks respectively, once a week for 4 consecutive weeks, after treatments for 42 days, observe the histological changes of dermal thickness, hydroxyproline, and expression of Periostin and Dermatopontin in every individual group. Results: Mesotherapy with intradermal co-injection of 0.1% DMAE+AA and 0.1% DMAE + AA have significantly increased the dermal thickness, hydroxyproline content and Periostin expression levels increased significantly, but did not affect the expression of Dermatopontin. Conclusion: by local co-injection of DMAE and AA compound directly under aged rats can effectively reform aged skin tissue structure and the degeneration of collagen, meanwhile it can improve collagen synthesis in aging skin and significantly increases the dermal thickness and collagen content of the skin, and thus prevent skin aging.

Dimethylaminoethano, Amino acid, anti-aging, D-galactose, Dermatopontin, Periostin

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